منابع مشابه
Endocytic entry of HIV-1
Enveloped viruses enter target cells by membrane fusion or endocytosis. In the latter case, fusion of the viral envelope is induced by the acidic pH of the endocytic vesicle [1]. As with most other retroviruses, entry of the human immunodeficiency virus (HIV) is thought to be exclusively by pH-independent membrane fusion after interaction of its envelope with CD4 and a chemokine co-receptor on ...
متن کاملInhibiting HIV-1 Entry Discovery of D-Peptide Inhibitors that Target the gp41 Coiled-Coil Pocket
The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and mirror-image phage display, we identified cyc...
متن کاملHIV-1 Entry, Inhibitors, and Resistance
Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity f...
متن کاملHIV-1 entry into renal epithelia.
Presence of HIV-1 nucleic acid in both glomerular and tubular cells indicates that the kidney may serve as a reservoir for HIV-1.1,2 Moreover, HIV-1 genes express in tubular epithelial cells in the absence of detectable viral load in HIV-associated nephropathy (HIVAN).3 Although these studies offered strong evidence for renal epithelial cell infection, the mechanism of HIV-1 entry is not clear....
متن کاملHIV-1: Cofactors provide the entry keys
The entry pathway of the human immunodeficiency virus type-1 (HIV-1) can be divided into three major events: binding, activation and fusion. The viral envelope protein is essential for each of these stages; it consists of a surface subunit, gp120, and a transmembrane subunit, gp41, which form an oligomeric complex in the virion membrane [1]. The gp120 subunit contains a binding domain specific ...
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80066-5